Due to numerous compatibility issues, the "layer skip" node is disabled by default. It allows for better video quality but causes frequent crashes.

You can read my guide to using this workflow: link

The easiest way to install all the files needed for workflow use is to use one of my installation scripts.
To only install the missing nodes, I created another script.

To save a lot of time on video generation, you can install SageAttention. I've written a guide on the subject: link

Resources you need:

Files :

Recommendation :
24 gb Vram: Q8_0
16 gb Vram: Q5_K_S
<12 gb Vram: Q4_K_S

I2V Quant Model: city96/Wan2.1-T2V-14B-gguf at main
In models/diffusion_models

CLIP : split_files/text_encoders/umt5_xxl_fp8_e4m3fn_scaled.safetensors · Comfy-Org/Wan_2.1_ComfyUI_repackaged at main
in models/clip

CLIP-VISION: split_files/clip_vision/clip_vision_h.safetensors · Comfy-Org/Wan_2.1_ComfyUI_repackaged at main
in models/clip_vision

VAE: split_files/vae/wan_2.1_vae.safetensors · Comfy-Org/Wan_2.1_ComfyUI_repackaged at main
in models/vae

ANY UPSCALE MODEL:

• Realistic : RealESRGAN_x4plus.pth · Marne/Real-ESRGAN at main

• Anime : RealESRGAN_x4plus_anime_6B.pth · Marne/Real-ESRGAN at main

in models/upscale_models

Custom Nodes :

• ComfyUI-Custom-Scripts

• ComfyUI-GGUF

• ComfyUI-KJNodes

• ComfyUI-VideoHelperSuite

• ComfyUI-mxToolkit

• ComfyUI-HunyuanVideoMultiLora

• rgthree-comfy

• ComfyUI-Frame-Interpolation