Bite that lip!
Wan 2.2 I2V v1
Definitely happier with this run than the last one. Still recommend highest resolution you can manage. Also, I had really terrible results using SmoothMix checkpoint. Not sure why. Best results I have seen are using the base wan. Test videos use Q6_K.gguf models. Also, I recommend messing with the lightning lora weight. I got better stability using 1-1.5 weight on lightning lora, or 2-2.5 if using other loras for sex acts for more speed/movement.
Wan 2.2 I2V v0.1
I'm seeing better results at higher resolution. So 720x1280 seems to be the best. Lower resolutions have sometimes worked, but only if the face is large and the primary focus of the image. My guess is that in the compressed latent space, the lips are just too small at lower resolution for the model to focus on, much less for the Lora to affect. So if you need small resolution, make sure the lips are big in the image reference.
I have a version of the core workflow I use here:
https://civitai.com/models/2076123/wils-style-workflow